Single-Ended and Differentially Operated Microwave Microfluidic Sensors for Biomedical Applications

Abstract

Background: This research is focused on the design of highly sensitive microfluidic sensors for the applications in liquid dielectric characterizations including biomedical samples. Methods: Considering the narrow?band operation of microfluidic sensors based on microwave resonators, in this study, microfluidic sensors based on the variation of transmission phase in microwave transmission lines (TLs) are proposed. It is shown that among different microwave TLs, slot-lines are an appropriate type of TL for sensing applications because a major portion of the electromagnetic (EM) field passes above the line, where a microfluidic channel can be easily devised. Results: The proposed concept is presented and the functionality of the proposed sensor is validated through full-wave EM simulations. Moreover, the effects of the dimensions of the microfluidic channel and the thickness of the substrate on the sensitivity of the sensor are studied. Furthermore, taking the advantages of differential circuits and systems into account, a differential version of the microfluidic sensor is also presented. It is shown that the sensitivity of the sensor can be adjusted according to the application. Specifically speaking, the sensitivity of the proposed microfluidic sensor is almost linearly proportional to the length of the channel, i.e., the sensitivity can be doubled by doubling the channel length. Conclusions: In this research, it is shown that using slot-line TLs highly sensitive microfluidic sensors can be designed for the applications in liquid dielectric characterizations, especially for biomedical samples where small variations of permittivity have to be detected.