99mTc-Phytate Lymphoscintigraphy for Detection of Sentinel Node: Preliminary Results of the First Year's Clinical Experience in Isfahan, Iran

Abstract

Sentinel lymph node is the first regional lymph node that drains the lymph from the primary tumor. It is potentially the first nodeto receive the seeding of lymph‑borne metastatic cells. This study aimed to discuss lymphoscintigraphy procedural guidelines fordetection of sentinel node using Tc‑Phytate in Isfahan, Iran. Moreover, the preliminary results of the first year’s clinical experience oflymphoscintigraphy in Isfahan, Iran are also presented. A total of 36 consecutive sentinel node procedures were performed followingour protocol in March 2013 to March 2014. For all 36 patients, after intradermal injection of 0.5–1 mCi of 99mTc‑Phytate, 5, 30 and120 min with hands up lymphoscintigraphy was performed. All procedures were performed in a 1‑day setting with Tc‑Phytate injectionin intradermal volume of about 0.1 cc. At 5, 30 and 120 min after injection, anterior and lateral images (4 min), were acquired usinggamma‑camera (energy 140 keV, window 15–20% and LEHR collimator). For all patients, at least one axillary sentinel lymph nodewas detected. For three patients, 2 SNs were seen. The images 5 min after injection showed at least one axillary sentinel node in 18 of36 patients. However for the remaining patients, more delayed images (after 30 and 120 min) were needed. Although, no changes wereseen in 120 min images compared to 30 min images. Considering the used protocol, from the evaluated data it can be concluded thatlymphoscintigraphy after 30 min periareolar injection of about 0.5–1 mCi Tc‑Phytate in an intradermal volume of about 0.1 cc yieldsan axillary sentinel node in all the patients. Imaging 120 min after injection is of no additional value and can be omitted.99m
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